Creutzfeldt-Jakob disease mimicking limbic encephalitis as a cause of rapid neurological deterioration.

ABSTRACT:

Background

A broad range of inflammatory and neurodegenerative conditions manifest with progressive cognitive and behavioural changes. A diagnostic challenge is the differentiation of limbic encephalitis (LE) from Creutzfeldt-Jakob disease (CJD). LE and CJD are distinct neurological conditions with distinct variations in their clinical course, with overlapping clinical presentations. LE can be subdivided into autoimmune paraneoplastic and non-paraneoplastic subtypes, under the umbrella of autoimmune LE. CJD is the most prevalent form of human prion disease and the subtype sporadic CJD (sCJD) the most common.

Case presentation

This case study presents a 68-year-old man with a 6-week history of progressive cognitive decline and behavioural changes, ultimately leading to a dire

SUBMITTER: Rajasingam V 

PROVIDER: S-EPMC11865761 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature