Effects of aspirin and omega-3 fatty acids on age-related macular degeneration in ASCEND-Eye: a randomised placebo-controlled trial in a population with diabetes.

ABSTRACT:

Purpose

Aspirin and omega-3 fatty acids (FAs) are potential disease modifiers of age-related macular degeneration (AMD), but previous studies have produced inconsistent findings. Randomised evidence for the efficacy and safety of aspirin and omega-3 FAs on AMD is presented in this study.

Design

ASCEND-Eye is a substudy of eye effects in the 2×2 factorial design ASCEND (A Study of Cardiovascular Events iN Diabetes) double-blind, randomised, placebo-controlled trial for the primary prevention of cardiovascular events. Reports of AMD diagnoses were sourced from 6 monthly ASCEND follow-up questionnaires and a Visual Function Questionnaire.

Participants

15 480 UK adults at least 40 years of age with diabetes but no evident cardiovascular disease.

Interventions

100 m

SUBMITTER: Sammons E 

PROVIDER: S-EPMC11865773 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature