Association of peripheral CD8⁺ T cell activation with disease activity and treatment resistance in systemic lupus erythematosus.

ABSTRACT:

Objective

Various immune-cell subsets intricately mediate the pathogenesis of systemic lupus erythematosus (SLE). However, the role of CD8⁺ T cells in SLE remains unclear. We investigated the proportions and characteristics of peripheral CD8⁺ T cells and their association with clinical manifestations of SLE.

Methods

We retrospectively enrolled 211 patients with SLE and 48 age- and sex-matched healthy controls (HCs). Peripheral CD8⁺ T cells were analysed using flow cytometry. The primary endpoint was the comparison of peripheral CD8⁺ T cell subset characteristics between patients and HCs.

Results

Patients with SLE (mean age, 42.3 years; women, 89% and mean disease duration, 112.8 months) had significantly higher proportions o

SUBMITTER: Fujita Y 

PROVIDER: S-EPMC11865784 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature