Effect of mono-guanidine-like derivatives on platelet aggregation and tumour cell induced platelet aggregation.

ABSTRACT: Antiplatelet agents are the cornerstone for the treatment and prevention of cardiovascular diseases. However, they can induce severe side effects such as gastrointestinal bleeding. The main aim of this study is to determine the effect that novel guanidine-based derivatives exert on platelet aggregation. From a screening, in collaboration with the Psychoactive Drug Screening Project service of several compounds from our in-house library of α2-adrenoceptors' ligands, four compounds showed high to medium affinity towards α2C-adrenoceptors and H2 histamine receptors. Based on the structure of these compounds, another two in-house α2-adrenoceptors' ligands were also selected. The effect of the six compounds on platelet aggregation was investigated by light transmission aggregometry and optical

SUBMITTER: Hante NK 

PROVIDER: S-EPMC11865921 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature