Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications.

ABSTRACT: Chronic wounds remain in a state of disrupted healing, impeding neurite outgrowth from injured nerves and poor development of new blood vessels by angiogenesis. Current therapeutic approaches primarily focus on the restoration of vascularization and overlook the need of nerve regeneration for complete healing. Vascular endothelial growth factor (VEGF) is a critical growth factor supporting angiogenesis in wound healing, promoting vascularization and has also demonstrated neuro-protective capabilities in both central and peripheral nervous system. While the delivery of pro-regenerative recombinant growth factors has shown promise, gene delivery offers greater stability, reduced off-target side effects, diminished cytotoxicity, and lower production costs. In this context, the overarching goa

SUBMITTER: Palomeque Chavez JC 

PROVIDER: S-EPMC11865941 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature