1-methylnicotinamide modulates IL-10 secretion and voriconazole metabolism.

ABSTRACT:

Background

Inflammatory diseases impair the hepatic metabolism of voriconazole (VRC). 1-Methylnicotinamide (1-MNA), a common final metabolite of nicotinamide in the liver, has demonstrated anti-inflammatory effects in recent studies. This study investigated the impact of 1-MNA on VRC metabolism in the liver.

Method

Mice with a systemic inflammatory response induced by lipopolysaccharide (LPS) were intragastrically administered 1-MNA, and their VRC metabolic capacity was evaluated. Kupffer cells and primary hepatocytes were isolated, and flow cytometry along with molecular knockdown experiments were performed to explore the molecular mechanisms underlying improved drug metabolism. IL-10 knockout (IL-10^-/-) mice were used to validate the role of IL-10 in enhancing h

SUBMITTER: Deng X 

PROVIDER: S-EPMC11865947 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature