Naphthalene peri-Diselenide-Based BODIPY Probe for the Detection of Hydrogen Peroxide, tert-Butylhydroperoxide, Hydroxyl Radical, and Peroxynitrite Ion.

ABSTRACT: Dimethoxynaphthalene peri-diselenide-based BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) probe has been synthesized. The probe demonstrated selectivity and sensitivity for hydrogen peroxide (H₂O₂) and tert-butylhydroperoxide (t-BuOOH), hydroxyl radical (^•OH), and peroxynitrite ion (ONOO^-) detection and reversibility upon treatment with glutathione. The limits of detection of the probe were observed to be 0.40 μM for H₂O₂, 0.41 μM for t-BuOOH, 0.95 μM for ^•OH, and 0.46 μM for ONOO^-, respectively. A proposed mechanism for the "turn-on" event has been suggested and corroborated by spectroscopic and computational data. It has been proposed that electron transfer occurred from the

SUBMITTER: Chhillar B 

PROVIDER: S-EPMC11865972 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature