Single-Photon DNA Photocleavage up to 905 nm by a Benzylated 4-Quinolinium Carbocyanine Dye.

ABSTRACT: This paper describes the DNA interactions of near-infrared (NIR) benzylated 4-quinolinium dicarbocyanine dyes containing a pentamethine bridge meso-substituted either with a bromine (4) or hydrogen (5) atom. In pH 7.0 buffered aqueous solutions, the 4-quinolinium dyes absorb light that extends into the near-infrared range up to ∼950 nm. The unique direct strand breakage of pUC19 DNA that is sensitized by irradiating either dicarbocyanine with an 850 nm LED laser constitutes the first published example of DNA photocleavage upon single-photon chromophore excitation at a wavelength greater than 830 nm. Brominated dye 4, which is more stable than and achieves DNA strand scission in higher yield than its hydrogen-bearing counterpart 5, cleaves plasmid DNA unde

SUBMITTER: Ahoulou EO 

PROVIDER: S-EPMC11865986 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature