In Situ Application of Berberine-Loaded Liposomes on the Treatment of Osteomyelitis.

ABSTRACT: Osteomyelitis is a major challenge in global healthcare, as it requires the simultaneous management of bone defects and bacterial infections, which poses considerable difficulties for orthopedic clinicians. In this study, we developed berberine liposome-modified bone cement specifically aimed at treating osteomyelitis induced by Staphylococcus aureus. We characterized the physical properties of this modified bone cement, conducted in vitro antibacterial assays to evaluate its efficacy in eradicating Staphylococcus aureus biofilm, established an in vivo rat model of osteomyelitis, and performed histopathological assessments alongside micro-CT analysis of bone parameters. The results indicated that the berberine liposome-modified bone cement exhibited favorable biodegradability

SUBMITTER: Wang S 

PROVIDER: S-EPMC11866016 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature