Efficacy and safety of H-APC in Barrett's esophagus: Italian prospective multicenter study.

ABSTRACT:

Background and study aims

Hybrid argon plasma coagulation (H-APC) is a novel technique for ablation of neoplastic Barrett's esophagus (BE), consisting in submucosal fluid injection and subsequent APC of visible BE. The aim of this study was to assess H-APC efficacy, safety, and tolerability.

Patients and methods

We prospectively included patients undergoing H-APC ablation at four Italian Hospitals from September 2022 to March 2024. Patients with BE C3M5 maximum extent, low- or high-grade dysplasia (LGD, HGD) or residual BE after endoscopic resection (ER) of visible lesions were included. Patients who had undergone previous ablative treatments were excluded. The primary endpoints were complete eradication of intestinal metaplasia (CE-IM) and dysplasia (CE-D). Secondary endpoi

SUBMITTER: Massimi D 

PROVIDER: S-EPMC11866041 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature