Risk of Major Adverse Cardiovascular Events Following Nicotinamide Exposure.

ABSTRACT:

Importance

Nicotinamide metabolites have recently been implicated in increased risk of major cardiovascular events (MACE). Supportive data about clinical risk of MACE for nicotinamide users is lacking.

Objective

To determine whether nicotinamide use results in an increase of MACE.

Design, setting, and participants

This study used retrospective electronic health record data of 2 patient cohorts, the Vanderbilt University Medical Center (VUMC) and Million Veteran Program (MVP). The risk of MACE in patients exposed to nicotinamide was compared with the risk of MACE in unexposed patients. In the VUMC cohort, patients were either exposed to nicotinamide based on keyword entry for nicotinamide or niacinamide and manual review of medical records or were unexposed but had doc

SUBMITTER: Wheless L 

PROVIDER: S-EPMC11866069 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature