Genetic Correlates of Treatment-Resistant Depression.

ABSTRACT:

Importance

Treatment-resistant depression (TRD) is a major challenge in mental health, affecting a significant number of patients and leading to considerable burdens. The etiological factors contributing to TRD are complex and not fully understood.

Objective

To investigate the genetic factors associated with TRD using polygenic scores (PGS) across various traits and explore their potential role in the etiology of TRD using large-scale genomic data from the All of Us (AoU) Research Program.

Design, setting, and participants

This study was a cohort design with observational data from participants in the AoU Research Program who have both electronic health records and genomic data. Data analysis was performed from March 27 to October 24, 2024.

Exposures

PGS for 61

SUBMITTER: Xu B 

PROVIDER: S-EPMC11866074 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature