3D-Printed Functionally Graded PCL-HA Scaffolds with Multi-Scale Porosity.

ABSTRACT: Functionally graded scaffolds (FGSs) designed for bone tissue regeneration exhibit three-dimensional (3D) constructs with spatially varying pores, mirroring the natural bone structure, aiming to offer temporary support and a conducive environment for cells during tissue regeneration in defect sites. While existing research on FGSs has primarily focused on altering pore architecture and tuning biomechanical properties for improved tissue regeneration, limited exploration exists on 3D spatially varying FGSs with multiscale porosity to closely mimic natural bone. In this study, we fabricated and investigated FGSs with macropores varying radially and longitudinally, along with micropores within the struts. Utilizing nonsolvent-induced phase separation integrated with 3D printing, we printed po

SUBMITTER: Bilgili HK 

PROVIDER: S-EPMC11866177 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature