Uptake of Biomimetic Nanovesicles by Granuloma for Photodynamic Therapy of Tuberculosis.

ABSTRACT: The antimicrobial resistance of Mycobacterium tuberculosis (M. tuberculosis) is a challenge in the antibiotic treatment of tuberculosis (TB). Herein, we aimed to examine a photodynamic therapy for TB that has a low risk of drug resistance and involves biomimetic macrophage membranes combined with a photosensitizer, chlorin e6 (Ce6; hereinafter, C-MV). We used Mycobacterium marinum (M. marinum), a waterborne pathogen closely related to M. tuberculosis, which causes TB-like infections in ectotherms but not in humans. The mouse tail granuloma model induced by M. marinum is a relatively mature TB model developed by our team. C-MV nanoparticles were prepared and injected intravenously, showing longevity in circulation due to the properties of the macrop

SUBMITTER: Wang H 

PROVIDER: S-EPMC11866195 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature