Toxicity of Pentachlorophenol Exposure on Male and Female Heteropneustes fossilis Investigated Using NMR-Based Metabolomics Approach.

ABSTRACT: Pentachlorophenol (PCP) is one of the most common chlorophenols utilized in numerous industrial processes, including the production of dyes, pesticides, wood preservatives, disinfectants, antiseptics, and medicines because it has fungicidal and bactericidal characteristics. Previous studies on catfish (Heteropneustes fossilis) revealed that PCP acts as a potent endocrine disruptor and also causes behavioral changes in a concentration-dependent manner. However, the toxicological effects of PCP have not been compared between male and female catfish. The present study aims to investigate the toxic effects of PCP on catfish through histopathological changes, oxidative stress, and serum metabolomics after 60 days of exposure. Chronic exposure to sublethal concentrations of PCP resulted i

SUBMITTER: Singh S 

PROVIDER: S-EPMC11866196 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature