Synthesis and Characterization of Novel Hydrazone Complexes: Exploring DNA/BSA Binding and Antimicrobial Potential.

ABSTRACT: Research involving coordination chemistry with Schiff base hydrazones finds applications in various areas, particularly in bioinorganic chemistry and biomedicine. This work aims to contribute to this field by employing the ligand (E)-2-((2-(benzothiazol-2-yl)hydrazone)methyl)phenol (H₂L), synthesized via a condensation reaction with salicylic aldehyde. The ligand was isolated, characterized, and subsequently complexed with nickel(II) chloride and copper(II) nitrate, yielding three new crystalline complexes: [Ni(HL)₂] (1), [Ni₂(L)₂(Py)₂(EtOH)]·DMF·0.5H₂O (2), and [Cu₃(L^#)₂(DMF)₂] (3) (where Py = pyridine). The metal complexes were structurally characterized usin

SUBMITTER: Moreira JM 

PROVIDER: S-EPMC11866212 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature