Development of a δ¹³C and δ³⁴S Isotope Analysis Method for Sulfadimidine and Its Potential to Trace Contaminant Transformation in Groundwater Systems.

ABSTRACT: The widespread occurrence of micropollutants like the antibiotic sulfadimidine in the environment has become a growing concern. Compound-specific stable isotope analysis (CSIA) offers a powerful tool for tracking the fate of such pollutants, but its application is often limited by low sensitivity. To address this limitation, a large-scale solid-phase extraction method was developed to extract, enrich, and isolate sulfadimidine for δ¹³C- and δ³⁴S-CSIA. Each step of the method was carefully evaluated, ensuring no detectable isotope artifacts. The limit of quantification was determined as 1.1 nmol of carbon and 1.2 nmol of sulfur directly injected on the column. Applied to groundwater samples from a contaminated site in Denmark, the method allowed for the analysis of con

SUBMITTER: Kummel S 

PROVIDER: S-EPMC11866275 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature