Progressive inner retinal neurodegeneration in non-proliferative macular telangiectasia type 2.

ABSTRACT:

Purpose

Patients with non-proliferative macular telangiectasia type 2 (MacTel) have ganglion cell layer (GCL) and nerve fibre layer (NFL) loss, but it is unclear whether the thinning is progressive. We quantified the change in retinal layer thickness over time in MacTel with and without diabetes.

Methods

In this retrospective, multicentre, comparative case series, subjects with MacTel with at least two optical coherence tomographic (OCT) scans separated by >9 months OCTs were segmented using the Iowa Reference Algorithms. Mean NFL and GCL thickness was computed across the total area of the early treatment diabetic retinopathy study grid and for the inner temporal region to determine the rate of thinning over time. Mixed effects models were fit to each layer and region to det

SUBMITTER: Amram AL 

PROVIDER: S-EPMC11866295 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature