CircFOXK2 Stabilizes STMN1 mRNA via PABPC1 to Promote the Progression of NSCLC.

ABSTRACT:

Background

Lung cancer has a notably high incidence and mortality rate, and understanding its occurrence and development is crucial for effective treatment. Circular RNA is closely associated with tumor progression, playing a role in tumorigenesis and development by regulating gene expression and influencing cell proliferation and apoptosis. This study aims to explore the circFOXK2 role in NSCLC occurrence and development and to elucidate its underlying mechanisms.

Methods

qRT-PCR and Western Blot analyzed the expressions of circFOXK2, STMN1, and PABPCA in NSCLC cell lines, as well as their relationships. The roles of circFOXK2 and STMN1 in the proliferation, invasion, and migration of NSCLC cells were assessed through CCK8, EDU, and Transwell experiments. RNA pulldown assay

SUBMITTER: Chen W 

PROVIDER: S-EPMC11866311 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature