How epigenetics impacts stroke risk and outcomes through DNA methylation: A systematic review.

ABSTRACT: The impact of DNA methylation (DNAm) on epigenetics has gained prominence in recent years due to its potential influence on ischemic stroke (IS) and treatment outcomes. DNAm is reversible and a better understanding of its role in IS could help identify novel therapeutic targets. The aim of this systematic review was to compile the available data on DNAm in the risk and prognosis of IS and to explore its therapeutic potential. The review process followed the PRISMA criteria. We searched the Pubmed and Cochrane databases to identify studies that used hypothesis free methodological approaches. Of the 459 studies identified, 34 met the inclusion criteria. The studies were categorized as follows: risk of IS; outcomes; and DNAm age. Most studies used genotyping array technology rather than whole

SUBMITTER: Gallego-Fabrega C 

PROVIDER: S-EPMC11866340 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature