Crystal structure of dihydroorotate dehydrogenase from Helicobacter pylori with bound flavin mononucleotide.

ABSTRACT: Helicobacter pylori is the primary causative agent of peptic ulcer disease, among other gastrointestinal ailments, and currently affects over half of the global population. Although some treatments exist, growing resistance to these drugs has prompted efforts to develop novel approaches to fighting this pathogen. To generate many of the nucleotides essential to biochemical processes, H. pylori relies exclusively on the de novo biosynthesis of these molecules. Recent drug-discovery efforts have targeted the first committed step of this pathway, catalysed by a class 2 dihydroorotate dehydrogenase (DHODH). However, these initiatives have been limited by the lack of a crystal structure. Here, we detail the crystal structure of H. pylori DHODH (HpDHODH) at 2.25 Å resolution (PDB entry 6b8s). We

SUBMITTER: Agarwal AA 

PROVIDER: S-EPMC11866409 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature