Effects of Systemic Anticancer Treatment on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Poor cardiorespiratory fitness (CRF) is associated with a higher symptom burden and an increased prevalence of long-term treatment-related cardiovascular disease risk factors in cancer survivors. However, the magnitude of systemic therapy-related CRF impairment remains unclear.

Objectives

The aim of this study was to evaluate the effects of systemic anticancer treatment on CRF and identify physiological determinants underpinning CRF impairment.

Methods

A systematic literature search was performed in PubMed, Embase, CINAHL, SPORTDiscus, and the Cochrane Library. The primary endpoint was the change in CRF, measured by peak oxygen consumption (Vo_2peak), from before to after systemic treatment. Secondary endpoints included post-treatment differences

SUBMITTER: Johansen SH 

PROVIDER: S-EPMC11866419 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature