SGLT2i Therapy Prevents Anthracycline-Induced Cardiotoxicity in a Large Animal Model by Preserving Myocardial Energetics.

ABSTRACT:

Background

Anthracycline-induced cardiotoxicity (AIC) is characterized by a disruption in myocardial metabolism.

Objectives

The authors used a large animal model to test sodium-glucose cotransporter inhibitor therapy to prevent AIC.

Methods

Female large white pigs (n = 36) were used to identify the most translational AIC regimen: 6 triweekly intravenous doxorubicin injections (1.8 mg/kg each). Another group of 32 pigs were randomized (1:1:2) to doxorubicin plus empagliflozin 20 mg, doxorubicin plus empagliflozin 10 mg, or doxorubicin control. Pigs were serially examined using multiparametric cardiac magnetic resonance and magnetic resonance spectroscopy. At the end of the 21-week follow-up period, blood samples were obtained to measure myocardial metabolic substrate e

SUBMITTER: Medina-Hernandez D 

PROVIDER: S-EPMC11866421 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature