The Association of Malignancy With Stroke and Bleeding in Atrial Fibrillation: A Population-Based Cohort Study.

ABSTRACT:

Background

It is undetermined if malignancy independently increases stroke risk in atrial fibrillation (AF).

Objectives

This study sought to determine the association of malignancy with stroke and bleeding in AF.

Methods

Population-based cohort study using administrative datasets of people aged ≥66 years with newly diagnosed AF. People diagnosed with malignancy within 5 years before AF diagnosis were matched to cancer-free control subjects on age, sex, AF diagnosis details, CHA₂DS₂-VASc score, and ATRIA bleeding score. Outcomes included hospitalizations for stroke and hospitalization/emergency visits for bleeding. Cause-specific regression was used to determine the HR for malignancy after adjusting for time-varying anticoagulation status. Analyse

SUBMITTER: El-Rayes M 

PROVIDER: S-EPMC11866432 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature