Atorvastatin and Myocardial Extracellular Volume Expansion During Anthracycline-Based Chemotherapy.

ABSTRACT:

Background

In the STOP-CA (Statins to Prevent the Cardiotoxicity From Anthracyclines) trial, atorvastatin preserved the left ventricular ejection fraction among patients with lymphoma treated with anthracyclines. The protective mechanisms are currently unclear.

Objectives

The aim of this study was to test the effect of atorvastatin on the anthracycline-associated increase in myocardial extracellular volume (ECV) using cardiac magnetic resonance imaging (MRI).

Methods

Cardiac MRI with mapping was performed at baseline and at 12-month follow-up. ECV was calculated, and the primary endpoint was a ≥3% increase. Increases of ≥1 SD in native T1 and T2 times and ECV were secondary endpoints.

Results

The subgroup included 171 participants with paired cardiac MRI scans,

SUBMITTER: Juhasz V 

PROVIDER: S-EPMC11866434 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature