A functional cardiac patch promotes cardiac repair by modulating the CCR2^- cardiac-resident macrophage niche and their cell crosstalk.

ABSTRACT: C-C chemokine receptor type 2 (CCR2^-) cardiac-resident macrophages (CCR2^- cRMs) are known to promote cardiac repair after myocardial infarction (MI). However, the substantial depletion and slow recovery of CCR2^- cRMs pose significant barriers in cardiac recovery. Here, we construct a functional conductive cardiac patch (CCP) that can provide exogenously elastic conductive microenvironment and induce endogenously reparative microenvironment mediated by CCR2^- cRMs for MI repair. This CCP exhibits suitable mechanical properties, conductivity, and high water retention, reminiscent of natural myocardium, which can actively engage in modulating CCR2^- cRM renewal and their cell crosstalk. The functional CCP can promote the expression of Conne

SUBMITTER: Ding C 

PROVIDER: S-EPMC11866506 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature