Chemosensory and cardiometabolic improvements after a fasting-mimicking diet: A randomized cross-over clinical trial.

ABSTRACT: Obesity is associated with a decrease in chemosensory perception acuity and increased disease risk, pointing to the need for feasible interventions that affect smell, taste, and cardiometabolic markers. Here, subjects with overweight/obesity are treated with six monthly cycles of a fasting-mimicking diet (FMD) lasting 5 days followed by a normal diet for the rest of the month to determine their effects on chemosensory function and cardiometabolic risk factors. Both arms of the 102 randomized cross-over trial participants indicate FMD-dependent improvements in a wide range of taste and smell chemosensory functions. The portion of hyposmic subjects is reduced from 38.1% at baseline to 6.4% at the end of 6 FMD cycles. FMD cycles also reduce cardiometabolic and inflammatory markers and drug us

SUBMITTER: Micarelli A 

PROVIDER: S-EPMC11866515 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature