Bioinformatics analysis of shared biomarkers and immune pathways of preeclampsia and periodontitis.

ABSTRACT:

Background

Epidemiological evidence indicates that preeclampsia (PE) is associated with comorbidities such as periodontitis (PD). However, the underlying mechanism remains unclear. To enhance our understanding of their co-pathogenesis, this research investigated the shared biomarkers and pathological mechanisms.

Methods

We systematically retrieved transcriptomic datasets from the Gene Expression Omnibus database. These datasets encompass a comparative analysis of the periodontium with and without PD and of the placenta with and without PE. Differentially Expressed Genes Analysis and Weighted Gene Go-expression Network Analysis (WGCNA) were used to identify the key crosstalk genes in patients with PD and PE. The functional characterisation of these genes was performed using e

SUBMITTER: Ruan F 

PROVIDER: S-EPMC11866586 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature