Total cardiolipin levels in gastric and colon cancer: evaluating the prognostic potential.

ABSTRACT:

Background

Cardiolipin (CL) is a signature phospholipid of mitochondria that maintains the integrity of mitochondrial membrane and supports proper mitochondrial function. Alterations in CL level and composition can impair or, conversely, improve mitochondrial function and bioenergetics, both of which are critical for cancer metabolism. However, conflicting reports on CL levels across different cancer types and limited research using human patient samples limit our understanding of its diagnostic potential.

Methods

This cross-sectional study explores CL concentrations in gastric and colon cancer tissues using a CL-specific fluorescent probe MitoCLue and compares them to adjacent healthy tissues.

Results

In gastric cancer, CL levels showed no significant differences bet

SUBMITTER: Dimitrijevs P 

PROVIDER: S-EPMC11866619 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature