Gut microbiota in chronic obstructive pulmonary disease varies by CT-verified emphysema status.

ABSTRACT:

Background and aim

The association of the gut microbiota to chronic obstructive pulmonary disease (COPD) phenotypes is underexplored. We aimed to compare stool samples from patients with COPD and subjects without COPD and relate findings to emphysema status, exacerbation rate, blood eosinophil levels, symptom score, and lung function.

Methods

We report findings from a single-centre case-control study with 62 current and former smoking patients with COPD and 49 subjects without COPD. DNA was extracted from stool samples, and the V3V4-region of the bacterial 16S-rRNA gene was sequenced. Emphysema was defined based on thoracic computed tomography (CT thorax) low attenuating areas ≥/<10% at threshold -950 and -910 hounsfield units, respectively. Differential abundance of taxa wa

SUBMITTER: Rotevatn AO 

PROVIDER: S-EPMC11866649 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature