Mediated roles of oxidative stress and kidney function to leukocyte telomere length and prognosis in chronic kidney disease.

ABSTRACT:

Background

Few studies have focused on the correlation between leukocyte telomere length (LTL) and cancer-related mortality or identified potential factors that mediate the relationship between LTL and mortality among chronic kidney disease (CKD) patients. Our study aimed to explore the associations between LTL and all-cause and cause-specific mortality and to identify the underlying mediators.

Methods

CKD patients were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. Cox regression analysis and restricted cubic spline analysis were used to explore the associations between LTL and all-cause or specific-cause mortality and their nonlinear connections. Stratified analyses were executed to assess the relationships among the different subgro

SUBMITTER: Yi J 

PROVIDER: S-EPMC11866651 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature