Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury.

ABSTRACT: Acute respiratory distress syndrome (ARDS) has emerged as a significant global health challenge, with no definitive curative treatment available. Recent evidence suggests that pyroptosis of immune cells plays a pivotal role in the pathogenesis of ARDS. Targeting and modulating immune cell pyroptosis in lung tissue may offer a promising strategy to mitigate the harmful inflammation associated with this condition. In this study, we designed and synthesized a novel class of peptide-functionalized nanoparticles, PV-K, which possess an intrinsic capacity for phagocytosis by macrophages. Concurrently, the incorporation of two FFD functional groups into a single polypeptide enhances the biological activity of PV-K. Amazingly, PV-K demonstrated potent inhibitory effects on nucleotide-binding domai

SUBMITTER: Fan Y 

PROVIDER: S-EPMC11866711 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature