Integrative transcriptomic and metabolomic analyses reveal the role of melatonin in promoting secondary hair follicle development in cashmere goats.

ABSTRACT:

Background

Melatonin improves the production performance of animal furs, particularly in promoting wool and cashmere growth. Although most studies of melatonin enhancing cashmere growth have focused primarily on gene and phenotype levels, its impact on metabolites has not received attention. To investigate the influence of melatonin on metabolites, genes, gene‒metabolite interactions, and associated signaling pathways in secondary hair follicles (SHFs), we performed multiomics analyses of skin and blood samples collected 30 days after sustained melatonin release.

Results

The results demonstrated that two melatonin interventions during SHF anagen in cashmere goats induce the early growth of SHFs, increase the active secondary follicle density (ASFD), and improve cashmere yiel

SUBMITTER: Diao X 

PROVIDER: S-EPMC11866715 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature