The predictive function of miR-122-5p and its action mechanism by regulating PKM2 in metabolic syndrome.

ABSTRACT:

Background

Obesity will cause metabolic syndrome (Mets) easily, and its pathogenesis is not completely clear.

Aim

To probe into the predictive value of miR-122-5p and its regulatory mechanism in Mets.

Method

The predictive effect of miR-122-5p on Mets was evaluated by constructing a Receiver Operating Characteristic (ROC) curve. The target genes of miR-122-5p were predicted using the ENCORI/starBase and TargetScanHuman databases, and pyruvate kinase M2 (PKM2), closely related to Mets, was screened by GO and KEGG analysis. The roles of miR-122-5p/PKM2 in insulin resistance (IR) were explored by treating the human normal liver cells (HLCs) with palmitic acid (PA) to induce the IR model. The effects of miR-122-5p/PKM2 on glucose metabolism (GM) of HLCs were evaluated by

SUBMITTER: Zhou X 

PROVIDER: S-EPMC11866723 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature