CircZNF707 promoted glycolysis and tumor progression through miR-668-3p-PFKM axis in NSCLC.

ABSTRACT:

Background

Circular RNA (circRNA) plays an important regulatory role in the development of human malignancies, but the potential mechanisms of circRNA in non-small cell lung cancer (NSCLC) remain largely unknown.

Methods

Microarray analysis was used to test for circRNAs differing in expression between NSCLC tumors and healthy adjacent tissues. Using qRT-PCR, the expression of circZNF707 was determined. Through a number of loss-of-function and gain-of-function investigations, the biological behavior of NSCLC cells was evaluated. Finally, tests using Western blotting, RIP, qRT-PCR, and luciferase reporter gene detection and rescue assays revealed the potential mechanism of circZNF707.

Results

Increased expression of circZNF707 was found in NSCLC tissues. Functionally, c

SUBMITTER: Chen W 

PROVIDER: S-EPMC11866724 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature