Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature-induced periodontitis in mice.

ABSTRACT:

Background

Bacterial-induced inflammation instigates the destruction of hard and soft tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity of osteoclasts induces the resorption of alveolar bones, ultimately leading to tooth loss. Because of their diverse chemical structures and bioactivities, natural compounds are often suggested to treat a wide variety of diseases, including inflammatory disorders.

Methods

In the present study, we demonstrated an inhibitory effect of gossypetin, a hexahydroxy flavone, on osteoclast differentiation and bone resorption using in vitro culture of osteoclasts from mouse bone marrow macrophage (BMM) precursors and in vivo model of ligature-induced periodontitis in mice.

Results

Gossypetin significa

SUBMITTER: Seok J 

PROVIDER: S-EPMC11866740 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature