Mendelian randomization reveals plasminogen as a common therapeutic target for myocardial infarction and atrial fibrillation.

ABSTRACT:

Introduction

Plasma proteins play essential roles in myocardial infarction (MI) and atrial fibrillation (AF); however, it remains unknown whether the two disorders share causal plasma proteins.

Methods

The present study utilizes cis-protein quantitative trait loci (cis-pQTLs) for 4,719 plasma proteins to assess their causality on MI and AF.

Results

Two-sample Mendelian randomization (MR) identifies 21 and 9 plasma proteins for MI and AF, respectively (FDR P<0.05), with plasminogen (PLG) being a commonly protective factor against both diseases. Multi-trait MR suggests that PLG is also protective against coronary atherosclerosis. PheWAS analysis identifies associations of six cis-pQTLs with both MI and AF, i.e., rs11751347 (PLG), rs11591147 (PCSK9), rs7734

SUBMITTER: Charati H 

PROVIDER: S-EPMC11866770 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature