A comparative proteomic-based study identifies essential factors involved in hair follicle growth in inner Mongolia cashmere goats.

ABSTRACT: Renowned for its invaluable undercoat, the cashmere goat is well known. The growth of cashmere fibre initiates when the relatively inactive telogen stage transitions to the anagen stage, which involves active proliferation. However, the molecular mechanisms responsible for this process are still unclear. Here, SWATH mass spectrometry (MS), a comparative proteomic analysis, was conducted to examine the proteomic alterations in Inner Mongolia cashmere goat skin samples at two different developmental stages (anagen and telogen). In total, 2414 proteins were detected, with 631 proteins showing differential regulation (503 upregulated proteins and 128 downregulated proteins). Bioinformatic analysis revealed that these proteins, which are differentially regulated, play crucial roles in the pathw

SUBMITTER: Nai R 

PROVIDER: S-EPMC11866830 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature