Brain age mediates gut microbiome dysbiosis-related cognition in older adults.

ABSTRACT:

Background

Recent studies have focused on improving our understanding of gut microbiome dysbiosis and its impact on cognitive function. However, the relationship between gut microbiome composition, accelerated brain atrophy, and cognitive function has not yet been fully explored.

Methods

We recruited 292 participants from South Korean memory clinics to undergo brain magnetic resonance imaging, clinical assessments, and collected stool samples. We employed a pretrained brain age model- a measure associated with neurodegeneration. Using cluster analysis, we categorized individuals based on their microbiome profiles and examined the correlations with brain age, Mental State Examination (MMSE) scores, and the Clinical Dementia Rating Sum of Box (CDR-SB).

Results

Two clust

SUBMITTER: Son SJ 

PROVIDER: S-EPMC11866832 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature