Black phosphorus nanosheets encapsulated microneedle for multifunctional therapy for androgenic alopecia.

ABSTRACT:

Background

Androgenetic alopecia (AGA), a chronic and progressive disease, significantly impacts the patients' social, emotional, and mental well-being. Current treatment for AGA are mainly limited by drug side effects and the stratum corneum (SC) barrier of scalp.

Results

To address these issues, we developed a microneedle (MN) system loaded with black phosphorus nanosheets (BP) encapsulating baicalin (BA), a natural ingredient, for effective treatment of AGA. We first fabricated BP-BA based on the BP properties of high drug loading capacity and excellent photothermal conversion efficiency. Upon 635 nm laser irradiation, BP-BA demonstrated efficient photothermal conversion to mild thermal of ~ 42 °C. This mild thermal effect controlled BA's stimuli-responsive release, enhan

SUBMITTER: Xiong S 

PROVIDER: S-EPMC11866876 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature