Modulatory effects of Kratom extract on the gut microbiota of rats: implications for health.

ABSTRACT:

Background

Kratom (Mitragyna speciosa), a plant native to Southeast Asia, is commonly used as a supplement for fatigue, pain relief, mood enhancement, and euphoria. Kratom extract exhibits diverse pharmacological properties, including antioxidant, anti-inflammatory, and gastrointestinal effects, with studies showing its ability to modulate gut microbiota and stimulate beneficial bacteria growth. Given these properties, kratom treatment may produce significant effects in a rat model, warranting further investigation.

Methods

Male Wistar rats were administered kratom extract orally on a daily basis for 28 days. Fresh fecal samples were collected and analyzed for changes in gut microbiome composition using 16S rRNA sequencing. Hematological parameters and lipid profiles were al

SUBMITTER: Thongsepee N 

PROVIDER: S-EPMC11866890 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature