Free triiodothyronine and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis.

ABSTRACT:

Background

Free triiodothyronine (FT3) exerts a significant influence on glucose metabolism. The relationship between gestational diabetes mellitus (GDM) and FT3 during pregnancy is complex and inconsistently reported. Our study aims to explore the bidirectional association between FT3 during pregnancy and GDM, and to assess whether this association is causal.

Methods

The observational analysis included two clinical studies. Study 1 involved 6,221 pregnant women and applied multivariate logistic regression analysis to investigate the association between FT3 in early pregnancy and the subsequent risk of GDM. Study 2 comprised 387 pregnant women and employed linear regression analysis to examine the impact of GDM on FT3 in late pregnancy. Additionally, genome-wide association

SUBMITTER: Li Y 

PROVIDER: S-EPMC11866897 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature