Modulating the Aqueous Micellar Reorganization of Sequence-Defined Ionic Peptoid Block Copolymers by Ionizable Monomer Position and Solution pH.

ABSTRACT: The micellar aggregation of singly charged sequence-defined ionic peptoid block copolymers can be finely tuned by adjusting the position of the ionizable monomer along the chain and varying the solution pH. The pH-induced structural reorganization of these micelles was found to depend on the position of the ionizable monomer along the chain, influencing the balance of the hydrophobic interactions, excluded volume effect, and electrostatic forces (i.e., charge repulsion, solvation of the ionic monomers, counterion association) that govern the micellar structure. As the solution pH increases, positioning the ionizable monomer closer to the junction of the hydrophobic and hydrophilic blocks causes a larger reduction in the micellar size and aggregation number across two distinct regimes. In c

SUBMITTER: Barrett BN 

PROVIDER: S-EPMC11866915 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature