Comprehensive Mass Spectrometry Workflows to Systematically Elucidate Transformation Processes of Organic Micropollutants: A Case Study on the Photodegradation of Four Pharmaceuticals.

ABSTRACT: Organic micropollutants (OMPs) in the aquatic environment challenge conventional water treatment processes. Advanced oxidation processes, such as UV photolysis, serve as effective strategies to remove OMPs. However, these often yield unknown transformation products (TPs). High-resolution mass spectrometry (HRMS)-based non-target analysis (NTA) is commonly used to screen large numbers of chemicals but faces specific challenges such as low concentrations of compounds of interest, lack of reference standards, and the need for sophisticated data analysis workflows when used for TP identification. This article describes comprehensive workflows to study UV photolysis-related processes and the resulting TPs, by combining an automated photodegradation setup and HRMS and advanced NTA approaches. Fo

SUBMITTER: Helmus R 

PROVIDER: S-EPMC11866921 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature