Subthalamic Nucleus Deep Brain Stimulation in the Beta Frequency Range Boosts Cortical Beta Oscillations and Slows Down Movement.

ABSTRACT: Recordings from Parkinson's disease (PD) patients show strong beta-band oscillations (13-35 Hz), which can be modulated by deep brain stimulation (DBS). While high-frequency DBS (>100 Hz) ameliorates motor symptoms and reduces beta activity in the basal ganglia and motor cortex, the effects of low-frequency DBS (<30 Hz) are less clear. Clarifying these effects is relevant for the debate about the role of beta oscillations in motor slowing, which might be causal or epiphenomenal. Here, we investigated how subthalamic nucleus (STN) beta-band DBS affects cortical beta oscillations and motor performance. We recorded the magnetoencephalogram of 14 PD patients (nine males) with DBS implants while on their usual medication. Following a baseline recording (DBS OFF), we applied bipolar DBS at beta

SUBMITTER: Werner LM 

PROVIDER: S-EPMC11867002 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature