Presenting Antimicrobial Peptides on Poly(ethylene glycol): Star-Shaped vs Comb-Like Architectures.

ABSTRACT: Conjugating antimicrobial peptides (AMPs) to nonlinear polymers is a promising strategy to overcome the translational challenges of AMPs toward treating infections caused by antibiotic-resistant bacteria. Nonlinear polymers, and therefore conjugates, can be prepared with various architectures (e.g., star-shaped, comb-like, hyperbranched, etc.), however, the effects of polymer architecture on antimicrobial performance and related properties, like size and morphology in solution and secondary structure, are not yet well-understood. Here, we compare conjugates of the human chemokine-derived AMP stapled P9 with poly(ethylene glycol) (PEG) prepared in two of the major nonlinear architectures: star-shaped and comb-like. At comparable molecular weights and compositions (peptide wt %), comb-like c

SUBMITTER: Cui Z 

PROVIDER: S-EPMC11867009 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature