The number of central nervous system-driven symptoms predicts subsequent chronic primary pain: evidence from UK Biobank.

ABSTRACT:

Background

Chronic primary pain describes conditions where pain is the principal problem rather than a consequence of another disease. Primary pain is thought to be primarily owing to nociplastic pain (i.e. pain as a result of altered nociception despite the absence of tissue damage). Primary pain is often accompanied by other bothersome central nervous system (CNS)-driven symptoms, including disturbed sleep, mood, and cognition; however, it is unclear whether these symptoms precede onset of primary pain.

Methods

In a prospective cohort study of the UK Biobank, we examined adults with no self-reported recent or chronic pain at baseline. Using linked primary care record data, we investigated the association between the number of CNS-driven symptoms and subsequent incidence of

SUBMITTER: Kelleher E 

PROVIDER: S-EPMC11867065 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature