Genome-wide association study on chronic postsurgical pain in the UK Biobank.

ABSTRACT:

Background

Chronic postsurgical pain (CPSP) persists beyond the expected healing period after surgery, imposing a substantial burden on overall patient well-being. Unfortunately, CPSP often remains underdiagnosed and undertreated. To better understand the mechanism of CPSP development, we aimed to identify genetic variants associated with CPSP.

Methods

A genome-wide association study was conducted in a cohort of 95,931 individuals from the UK Biobank who had undergone different surgical procedures. Three analyses were performed: (1) case-control analysis (2923 cases with CPSP and 93,008 controls), (2) ordinal analysis in three groups based on time of analgesics use (n=95,931), and (3) a meta-analysis combining our dataset with a recent publication (n=97,281).

Results

SUBMITTER: Li S 

PROVIDER: S-EPMC11867066 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature