Kappa opioid receptor internalisation-induced p38 nuclear translocation suppresses glioma progression.

ABSTRACT:

Background

Recent studies have implicated a role for perioperative medications in determining patient outcomes after surgery for malignant tumours, including relapse and metastasis.

Methods

A combined approach spanned molecular, cellular, and organismal levels, including bioinformatics, immunohistochemical staining of clinical and animal samples, RNA sequencing of glioblastoma multiforme (GBM) cells with Ingenuity Pathway Analysis, lentiviral-mediated gene expression modulation, in vitro cell experiments, and in vivo orthotopic tumour transplantation.

Results

We observed a significant correlation between increased kappa opioid receptor (KOP receptor) expression and better prognosis in patients with glioma. Exogenous KOP receptor overexpression in GBM cells in vitro in

SUBMITTER: Li Y 

PROVIDER: S-EPMC11867070 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature