The relationship of bispectral index values to conscious state: an analysis of two volunteer cohort studies.

ABSTRACT:

Background

The ability of current depth-of-anaesthesia monitors to differentiate subtle changes in the conscious state has not been well characterised. We examine the variability in bispectral index (BIS) scores associated with disconnected conscious and unconscious states as confirmed by a novel serial awakening paradigm.

Methods

Seventy adult participants, given propofol or dexmedetomidine, had a cumulative 1381 electroencephalographic (EEG) recordings across two centres. Participants were awakened periodically, and their recent conscious experience interrogated by structured questioning. BIS were reconstructed from EEG using openibis, and the distribution of BIS scores were compared using linear mixed effects modelling. The predictive capacity of BIS across states of cons

SUBMITTER: Wehrman JJ 

PROVIDER: S-EPMC11867084 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature